What is Glyxambi?
Glyxambi is a medication designed to help manage blood sugar levels in adults with type 2 diabetes. It combines two active ingredients, empagliflozin and linagliptin, which work together to enhance glucose control. Empagliflozin supports the kidneys in removing excess glucose through urine, while linagliptin helps regulate insulin and glucagon levels to balance blood sugar more effectively. This dual-action approach makes the empagliflozin-linagliptin combo an effective option for those who struggle to keep their diabetes under control with lifestyle changes alone.
In addition to managing blood sugar, the dual-action diabetes pill has been shown to offer cardiovascular benefits, which is essential for many diabetes patients at higher risk of heart disease. As it assists the kidneys in filtering and removing glucose, it also may support kidney health in people with type 2 diabetes, an important consideration for patients with diabetes-related kidney concerns. Patients are encouraged to discuss the drug’s potential benefits and risks with their healthcare provider to ensure it aligns with their overall health needs.
Where to Buy Glyxambi
Comparing online pharmacies can help you find the best option for purchasing this medication for managing blood sugar in type 2 diabetes. Each of the trusted pharmacies listed below offers unique benefits, allowing you to choose based on price, service, and features. Here’s a breakdown to guide you in making an informed decision:
| Pharmacy | Price per Tablet | Top Benefits | Customer Rating |
|---|---|---|---|
| Canadian Pharmacy | $5.50 | 24/7 customer support, fastest delivery, best bulk deals | ★★★★★ (5.0) |
| North Drugstore | $4.27 | Reliable packaging, straightforward ordering | ★★★★☆ (4.6) |
| Canada Drugs Direct | $5.17 | Canadian-certified, easy online checkout | ★★★★☆ (4.5) |
| Rx Connected | $5.57 | Wide product selection, secure payment options | ★★★★☆ (4.7) |
| PricePro Pharmacy | $5.32 | Rewards program, helpful medication guides | ★★★★☆ (4.6) |
| NorthWest Pharmacy | $4.99 | Customer-focused, multilingual support available | ★★★★☆ (4.5) |
When choosing an online pharmacy for Glyxambi, take into account factors like ease of ordering, secure payment options, and customer ratings. Many pharmacies also offer rewards programs or bulk discounts to help lower costs over time. For safe and effective use, consult your healthcare provider regarding the proper dosage and administration instructions.
FAQ
When is Glyxambi used?
This drug is prescribed for adults with type 2 diabetes who require additional blood sugar control, particularly when other treatments alone are insufficient. This medication is beneficial for specific situations where both glucose management and cardiovascular health are essential. Common cases for Glyxambi use include:
- For adults with type 2 diabetes who have not achieved adequate blood sugar control with other medications
- To provide additional cardiovascular support for patients at risk of heart disease
- When reducing post-meal blood sugar spikes is important for better glucose stability
- For those who prefer a once-daily medication that simplifies their treatment routine
- As part of a comprehensive approach that combines lifestyle changes with medication for optimal diabetes management
The pill’s dual-action design supports these needs, making it an effective option for complex diabetes management.
How does it work?
Glyxambi combines two active ingredients, empagliflozin and linagliptin, to manage blood sugar levels in individuals with type 2 diabetes through a complementary dual-action approach. Empagliflozin, an SGLT2 inhibitor, helps the kidneys remove excess glucose from the body by increasing its excretion through urine. This process not only lowers blood sugar levels but can also support cardiovascular health by slightly reducing blood pressure and body weight. Meanwhile, linagliptin, a DPP-4 inhibitor, works differently by enhancing the body’s natural insulin response. It increases insulin release when blood sugar levels are high and lowers glucagon release, which helps to prevent the liver from producing excess glucose.
By targeting blood sugar from two separate angles, the medication offers a more comprehensive management solution than single-action medications. This combined effect helps maintain more stable blood sugar levels throughout the day, reducing post-meal spikes and supporting consistent glucose control. Together, these actions make the empagliflozin-linagliptin combo an effective choice for managing type 2 diabetes, especially for patients requiring additional cardiovascular benefits alongside glucose control.
Is Glyxambi the same as Jardiance?
No, these are different medications, although they share one active ingredient. Here’s a comparison:
| Aspect | Glyxambi | Jardiance |
|---|---|---|
| Active Ingredients | Empagliflozin and Linagliptin | Empagliflozin |
| Mechanism of Action | Dual action: increases glucose excretion through kidneys (empagliflozin) and regulates insulin/glucagon levels (linagliptin) | Increases glucose excretion through kidneys (empagliflozin) |
| Primary Use | For patients needing dual-action glucose management | For patients needing single-agent SGLT2 inhibitor |
| Blood Sugar Control | Comprehensive, targets blood sugar in multiple ways | Focused on glucose removal through kidneys |
Empagliflozin/linagliptin medication provides a broader approach to blood sugar control compared to Jardiance alone, making it suitable for individuals who may benefit from multi-mechanism therapy.
Is Glyxambi a metformin?
No, this drug is not a form of metformin. Metformin is a standalone medication used primarily to improve insulin sensitivity and reduce glucose production in the liver. The tablet, however, combines empagliflozin and linagliptin, targeting blood sugar levels differently by using both SGLT2 and DPP-4 inhibitors. While both Glyxambi and metformin are used to manage type 2 diabetes, they work through different mechanisms and are often prescribed together or in combination with other treatments to achieve optimal blood sugar control.
Is Glyxambi hard on the kidneys?
This dual-action diabetes pill is generally safe for kidney function when used as directed, but it may not be suitable for individuals with severe kidney disease. Since one of its active ingredients, empagliflozin, works by increasing glucose excretion through the kidneys, it does require healthy kidney function to be effective. For patients with mild to moderate kidney impairment, this tablet may still be prescribed, but regular kidney function monitoring is recommended. If you have any existing kidney concerns, it’s essential to discuss them with your healthcare provider to ensure this empagliflozin/linagliptin medication is a safe choice for your treatment plan.
How does Glyxambi compare to other diabetes medications?
This dual therapy for type 2 diabetes is distinct from many other diabetes medications because it combines two active ingredients—empagliflozin and linagliptin—to target blood sugar in multiple ways. Compared to medications like metformin or sulfonylureas, which focus solely on insulin sensitivity or production, the empagliflozin-linagliptin combo provides a dual approach. Empagliflozin helps the kidneys eliminate excess glucose, which isn’t a mechanism found in most other diabetes drugs. Linagliptin, meanwhile, regulates insulin and glucagon levels to prevent blood sugar spikes, providing additional control over glucose levels.
Here’s a comparison of Glyxambi with other common diabetes medications:
| Medication | Primary Action | Additional Benefits |
|---|---|---|
| Glyxambi | Kidney glucose excretion, insulin regulation | Cardiovascular risk reduction, modest weight loss |
| Metformin | Improves insulin sensitivity | Affordable, often first-line treatment |
| Sulfonylureas | Stimulates insulin production | Lower cost, widely available |
| GLP-1 receptor agonists | Increases insulin secretion and reduces appetite | Significant weight loss, once-weekly options |
Each medication has unique benefits and mechanisms, so the best choice depends on individual health goals, lifestyle, and specific medical needs.
What are the benefits of taking this drug for type 2 diabetes?
Glyxambi provides multiple benefits for individuals with type 2 diabetes, particularly in managing blood sugar and reducing cardiovascular risks. This combination medication works by using empagliflozin to help the kidneys remove excess glucose through urine, while linagliptin regulates insulin and glucagon levels to prevent blood sugar spikes. This SGLT2 and DPP-4 inhibitor blend has shown additional benefits for cardiovascular health, which is a critical consideration for many patients with diabetes, as it may help lower the risk of heart-related events. The medication has also demonstrated improvements in overall blood pressure and weight management for some users.
Key benefits of this combo diabetes pill include:
- Effective blood sugar control through dual action on kidneys and insulin regulation
- Reduced risk of cardiovascular events, such as heart attacks and hospitalizations for heart failure
- Helps with blood pressure management, supporting overall heart health
- Modest weight loss due to glucose excretion, potentially benefiting metabolic health
- Simple daily dosing, making it easy to incorporate into a daily routine
Empagliflozin-linagliptin treatment may serve as a comprehensive option for patients who need additional support in managing both blood sugar and cardiovascular health.
What is the recommended dosage, and how is it taken?
The typical starting dosage for Glyxambi is one tablet containing 10 mg of empagliflozin and 5 mg of linagliptin, taken once daily in the morning. This dosage is designed to provide an effective balance for blood sugar control while minimizing potential side effects. If a patient requires additional blood sugar management, a healthcare provider may increase the dosage to 25 mg of empagliflozin with 5 mg of linagliptin, still taken once daily. It’s essential to take the pill consistently at the same time each day, with or without food, to maintain stable blood sugar levels.
Dosage instructions for the type 2 diabetes dual-action pill:
- Starting Dose: 10 mg empagliflozin + 5 mg linagliptin, once daily
- Higher Dose (if necessary): 25 mg empagliflozin + 5 mg linagliptin, once daily
- Timing: Take in the morning, preferably at the same time each day
- With or Without Food: Can be taken with or without a meal
- Hydration: Maintain adequate hydration, as the empagliflozin-linagliptin mix can increase urine output
Following these dosing instructions helps optimize the medication’s effectiveness in managing type 2 diabetes. Always consult your healthcare provider before making any changes to the dosage.
Is there a generic version of Glyxambi available?
Yes, a generic version of Glyxambi is now available, offering an efficient and cost-effective option for managing type 2 diabetes. The generic combines empagliflozin and linagliptin, just like the brand-name version, providing similar benefits in blood sugar control and cardiovascular support. Research shows that patients using this combination therapy experience comparable results, with blood glucose levels improving by up to 20-25% and HbA1c levels decreasing by about 1-1.5% over a 24-week period.
The generic form is a more affordable choice, making it accessible to a broader range of patients without sacrificing the high effectiveness associated with the brand. For those managing long-term treatment costs, the generic option can be an excellent alternative, delivering the same therapeutic benefits at a lower price.
Can this pill help with weight management in type 2 diabetes?
While Glyxambi is primarily used to control blood sugar levels, some patients may experience modest weight loss as a secondary benefit. This effect is largely due to empagliflozin, one of this drug’s active ingredients, which helps remove excess glucose from the body through urine. This process can lead to a reduction in calories, which may contribute to weight loss over time. However, this glucose-lowering dual med is not specifically approved for weight management, and results can vary depending on individual factors.
For patients focused on weight management, it’s important to consider:
- Following a balanced, calorie-controlled diet
- Engaging in regular physical activity
- Monitoring weight changes to discuss with a healthcare provider
- Avoiding expectations of rapid weight loss, as this diabetes combination pill’s effect is modest
- Maintaining regular follow-ups to adjust lifestyle and medication as needed
Consulting with a healthcare provider about weight goals can help determine a comprehensive plan that supports both diabetes and weight management.
What are the potential side effects?
Glyxambi, like most medications, can have side effects, and it’s important for patients to be aware of them. Common side effects include symptoms like urinary tract infections, frequent urination, and mild nausea. Some people may experience symptoms related to dehydration, such as dizziness or lightheadedness, because the medication increases glucose excretion through urine. Less common but more serious side effects could include pancreatitis, kidney problems, or severe allergic reactions.
Below is a summary of empagliflozin and linagliptin side effects by severity:
| Type | Examples |
|---|---|
| Common | Urinary tract infections, nausea, dehydration symptoms |
| Less Common | Pancreatitis, joint pain, kidney issues |
| Serious | Severe allergic reaction, liver problems |
If any side effects seem severe or persistent, consulting with a healthcare provider can help determine the best course of action, including potential changes in dosage or alternative medications.
What should I do if I miss a dose?
If you miss a dose of Glyxambi, it’s generally recommended to take it as soon as you remember, unless it’s nearly time for your next dose. In that case, skip the missed dose and return to your regular dosing schedule. Avoid doubling up on doses to make up for a missed one, as this could increase the risk of side effects such as low blood sugar or dehydration. Consistency is key for empagliflozin and linagliptin to work effectively, so setting a daily reminder or using a medication organizer may be helpful.
When handling a missed dose, follow these tips:
- Take the missed dose as soon as you remember if it’s not close to the next dose
- Skip the missed dose if the next dose is soon due
- Never double up doses to compensate for a missed one
- Set a daily reminder or use a pill organizer
- Contact your healthcare provider if you miss doses frequently
Taking the tablet at the same time each day can also reduce the chances of missed doses and support stable blood sugar levels.
How should this drug be taken for best results?
To achieve the best results with Glyxambi, it’s typically taken once daily in the morning, with or without food, as directed by a healthcare provider. Consistency in the time of day you take it can help maintain stable blood sugar levels throughout the day. It’s important to follow the prescribed dose and avoid taking more than recommended. Staying hydrated is also essential, as the combo diabetes pill increases urine output, which can lead to dehydration. Drinking water regularly can help prevent this side effect.
For optimal results with empagliflozin/linagliptin medication, follow these guidelines:
- Take once daily in the morning
- Stick to the same time each day for consistency
- Follow your doctor’s dosage instructions exactly
- Monitor blood sugar levels as advised
- Drink plenty of water throughout the day
- Avoid missed doses, but do not double up if you miss one
Regular blood sugar monitoring and adherence to a balanced diet and exercise can further enhance the effectiveness of this drug in managing diabetes.
What monitoring is needed while taking these pills?
Regular monitoring is crucial while taking this blood sugar management combo to ensure that it effectively manages blood sugar levels and to catch any potential side effects early. Patients should routinely check their blood sugar levels, particularly if they experience symptoms of low blood sugar. In addition to blood sugar checks, kidney function tests are often recommended, as the kidneys play a key role in the drug’s glucose-excreting mechanism. Monitoring blood pressure is also beneficial since empagliflozin-linagliptin treatment can slightly lower blood pressure.
Essential monitoring with Glyxambi:
| Type of Monitoring | Purpose |
|---|---|
| Blood sugar levels | To ensure blood sugar is within target |
| Kidney function tests | To monitor kidney health |
| Blood pressure checks | To ensure safe blood pressure levels |
| Signs of dehydration | To avoid risks related to fluid loss |
| Regular doctor check-ups | To review overall treatment effectiveness |
By following a consistent monitoring plan, patients can help maintain the effectiveness of dual therapy for type 2 diabetes and minimize the risk of complications.
Is it safe to drink alcohol while taking this medication?
It is generally recommended to limit or avoid alcohol while taking the empagliflozin-linagliptin combo. Alcohol can lower blood sugar levels, increasing the risk of hypoglycemia, especially in people with diabetes. Additionally, both Glyxambi and alcohol can cause dehydration, so combining them may lead to more pronounced dehydration and other side effects. Drinking alcohol can also place additional stress on the kidneys, which may be concerning for individuals already managing kidney-related risks with diabetes.
Consider these risks when consuming alcohol with this diabetes combination pill:
- Increased risk of hypoglycemia (low blood sugar)
- Greater likelihood of dehydration due to fluid loss
- Added strain on kidney function, especially in diabetic patients
- Potential to interact negatively with blood sugar management
- Need for closer monitoring of blood sugar if consuming alcohol
Always consult your healthcare provider about alcohol intake to understand how it might interact with your specific treatment plan.
How should this drug be stored?
Proper storage of Glyxambi is essential to maintain its effectiveness. It should be kept at room temperature, away from direct light, heat, and moisture, in its original packaging. Avoid storing it in places with high humidity, such as bathrooms, and keep it out of reach of children and pets. If you have any unused medication past its expiration date, consult your pharmacist on how to dispose of it safely to prevent accidental use.
Key empagliflozin and linagliptin storage guidelines:
- Store at room temperature, ideally 20-25°C (68-77°F)
- Keep away from direct light, heat, and moisture
- Avoid high-humidity areas like bathrooms
- Keep out of reach of children and pets
- Dispose of expired medication through a pharmacy, if possible
Following these storage practices helps maintain the medication’s potency and safety.
Who should avoid using Glyxambi?
This SGLT2 and DPP-4 inhibitor blend may not be suitable for everyone, especially those with specific health conditions. People with type 1 diabetes, diabetic ketoacidosis, severe kidney disease, or a history of pancreatitis should generally avoid taking Glyxambi due to increased risks. It’s also advised that people who have severe liver problems or a history of serious urinary tract infections consult their doctor before starting this medication. Additionally, women who are pregnant or breastfeeding should avoid using this blood sugar-lowering combo, as it may not be safe for the fetus or nursing infant.
Patients should inform their healthcare provider if they:
- Have kidney disease or are on dialysis
- Have a history of severe urinary tract infections
- Are pregnant, planning to become pregnant, or breastfeeding
- Experience any liver issues or pancreatitis
- Have low blood pressure or are prone to dehydration
Discussing any pre-existing health conditions can help ensure that the dual therapy for type 2 diabetes is a safe and effective choice.
Can Glyxambi interact with other medications?
Yes, the empagliflozin-linagliptin combo can interact with other medications, so it’s essential to review all current medications with your healthcare provider before starting treatment. Certain medications, such as diuretics, insulin, or drugs that affect kidney function, may increase the risk of side effects or reduce the effectiveness of the diabetes combination pill. Medications like rifampin, used to treat bacterial infections, can decrease the effectiveness of linagliptin in the combo diabetes pill. Additionally, other diabetes medications may need dose adjustments to prevent low blood sugar.
Here’s a list of medications that may interact with empagliflozin and linagliptin:
- Diuretics (water pills) like furosemide
- Other diabetes medications, such as insulin or sulfonylureas
- Rifampin or other antibiotics affecting metabolism
- Antifungal medications, like ketoconazole
- Drugs affecting kidney function, such as NSAIDs
Consulting with a healthcare provider about any medications you’re taking, including over-the-counter drugs and supplements, can help prevent potential interactions.
What precautions should be taken when using these tablets?
Using Glyxambi requires certain precautions to ensure safety and effectiveness. Staying well-hydrated is essential since empagliflozin and linagliptin can increase urine production, which may lead to dehydration if fluids aren’t replenished. Additionally, because this drug can affect kidney function, regular kidney function tests are often recommended, especially for patients with pre-existing kidney concerns. It’s also wise to monitor blood sugar levels regularly, as this medication may affect glucose levels in various ways.
Key precautions for using this type 2 diabetes support include:
- Regular hydration to avoid dehydration
- Consistent blood sugar monitoring
- Routine kidney function tests, as advised by your doctor
- Awareness of potential side effects, such as low blood pressure
- Avoiding alcohol, which can impact blood sugar levels
- Informing your doctor of any severe urinary tract infections
Taking these precautions can help manage both the effectiveness and safety of this blood sugar-lowering combo in managing type 2 diabetes.
Disclaimer: This website offers information solely for educational purposes and is not intended as a replacement for professional medical advice, diagnosis, or treatment. Always seek advice from your doctor or a qualified healthcare provider if you have questions regarding a medical condition or treatment. Never disregard medical guidance or delay seeking it based on information from this site. If you think you may have a medical emergency, promptly contact your doctor or emergency services. Use of this site and any reliance on its information is at your own risk.
Written by Pepper Landson
Medically Reviewed by Monika Aggarwal, MD, MS (nephrologist)
Last Update on November 5, 2024