What is Invokana?
Invokana (Canagliflozin) is an FDA-approved medication used to manage blood sugar levels in adults with type 2 diabetes. As an SGLT2 inhibitor, the drug works by helping the kidneys remove excess glucose through urine, lowering blood sugar effectively. This mechanism of action makes it a valuable treatment for those who have not achieved adequate glucose control with diet and exercise alone. Taken once daily, the tablet can be part of a comprehensive diabetes management plan, potentially reducing the risk of long-term complications related to high blood sugar.
Beyond blood sugar control, canagliflozin tablets have shown additional benefits for heart and kidney health. Studies indicate that it may help lower the risk of cardiovascular events, such as heart attack and stroke, in people with diabetes. It has also been found to slow the progression of kidney disease in patients with type 2 diabetes, making it a promising option for those at higher risk of kidney complications. However, patients should consult their healthcare provider to determine if this type 2 diabetes management drug is the right choice, especially if they have pre-existing kidney conditions.
Where to Buy Invokana
Invokana (Canagliflozin) is available from several trusted online pharmacies, each offering unique benefits such as affordable pricing, secure transactions, and quality customer support. Below is a comparison of well-rated pharmacies, highlighting their price per pill, key benefits, and customer ratings to help you find the best fit for your needs.
| Pharmacy | Price per Pill | Top Benefits | Customer Rating |
|---|---|---|---|
| RxConnected | $3.10 | Lowest price, bulk discounts, user-friendly website | ★★★★☆ (4.8) |
| Canada Cloud Pharmacy | $4.33 | Affordable pricing, secure checkout, multilingual support | ★★★★☆ (4.6) |
| LifeRx Pharmacy | $4.89 | Comprehensive product range, secure packaging, personalized assistance | ★★★★☆ (4.7) |
| Canadian Pharmacy | $5.00 | Reliable shipping, 24/7 customer service, loyalty rewards | ★★★★★ (5.0) |
| AllDayChemist | $5.20 | Global shipping, frequent discounts, easy reordering | ★★★★☆ (4.5) |
| Pharmacy Planet | $5.30 | Fast processing, responsive support, various payment options | ★★★★☆ (4.7) |
These pharmacies provide convenient and secure options for purchasing canagliflozin 100 mg online. Consider factors like pricing, support, and delivery options to select the provider that best suits your needs.
FAQ
What is the drug Invokana used for?
Canagliflozin medication is primarily used to help manage blood sugar levels in adults with type 2 diabetes. It has several important applications and benefits, which include:
- Lowering Blood Sugar: This SGLT2 inhibitor blocks glucose reabsorption in the kidneys, which allows excess sugar to be excreted through urine, helping control blood glucose levels.
- Promoting Weight Loss: By reducing blood sugar, the drug may lead to a modest weight loss of 2-4% over several months.
- Reducing Blood Pressure: Some patients experience a mild drop in blood pressure, which can benefit those with hypertension.
- Providing Cardiovascular Benefits: According to the American Diabetes Association (ADA), the medication reduces the risk of cardiovascular events like heart attack and stroke by about 14% in high-risk patients.
- Supporting Kidney Health: The FDA has approved canagliflozin oral medication to slow the progression of kidney disease, with studies showing a 30% reduction in end-stage kidney disease risk for eligible patients.
- Complementing Other Diabetes Treatments: Invokana can be taken alongside other diabetes medications, such as metformin, to achieve better blood sugar control.
These multiple benefits make this oral diabetes medication an effective option for managing blood sugar, especially for those with additional heart or kidney concerns. Always follow your healthcare provider’s advice for best results.
How does it work?
Invokana, containing the active ingredient canagliflozin, works by inhibiting a specific protein in the kidneys called sodium-glucose co-transporter 2 (SGLT2). This protein is responsible for reabsorbing glucose back into the bloodstream, and by blocking it, canagliflozin allows excess glucose to be eliminated through urine. This mechanism helps lower blood glucose levels, which can benefit patients with type 2 diabetes. Additionally, the tablet may aid in weight loss, as it encourages the body to use fat stores for energy. This process can also improve insulin sensitivity, contributing to better blood sugar control over time. Some users also experience a reduction in blood pressure, adding cardiovascular benefits. However, it’s essential to monitor kidney function and blood sugar levels regularly while taking these pill, as it can have effects on hydration and electrolyte balance. Always follow your healthcare provider’s instructions for optimal results.
How should I take Invokana for the best results?
To maximize the effectiveness of canagliflozin tablets, follow these key guidelines:
- Take it once daily, preferably before breakfast: This timing helps control blood sugar throughout the day.
- Stay hydrated: The medication can increase urine output, so drinking water regularly is important to prevent dehydration.
- Avoid excessive alcohol: Alcohol can impact blood sugar levels and exacerbate potential side effects.
- Pair with a balanced diet and exercise: The drug is most effective when used alongside healthy lifestyle choices.
- Monitor blood sugar as directed: Keeping track of levels helps evaluate the drug’s effectiveness.
Following these recommendations can help you achieve the best results with canagliflozin oral medication. If you miss a dose, do not double up; simply take the next dose at the usual time.
Is the generic version of Invokana as effective as the brand name?
Yes, the generic version of Invokana, which also contains canagliflozin, is just as effective as the brand-name drug. Generics are required by regulatory agencies, such as the FDA, to have the same active ingredients, strength, and dosage form as their brand-name counterparts. This means the generic version works in the body in the same way to lower blood sugar levels by promoting glucose excretion through urine. The primary difference between the generic and brand-name medicine is the price—generic medications are often more affordable due to reduced development and marketing costs. Despite the lower cost, generics meet strict standards for safety, quality, and efficacy, offering patients a budget-friendly alternative without sacrificing effectiveness. Many people with type 2 diabetes opt for generics to reduce prescription expenses while achieving the same health benefits. Consult your healthcare provider or pharmacist about generic options to see if they might be a suitable choice for you.
What is the most common side effect of taking Invokana?
Invokana may cause several side effects, with the most common being urinary tract infections (UTIs) and genital yeast infections, particularly in women. This occurs due to the increased sugar in urine, which can create an environment for bacterial growth. Other frequent side effects include:
- Increased urination: This may lead to dehydration if fluid intake isn’t sufficient.
- Dizziness or lightheadedness: Often occurs when standing up too quickly, due to a drop in blood pressure.
- Ketoacidosis (rare): A serious condition that can require immediate medical attention. Symptoms to watch for include nausea, vomiting, and stomach pain.
Monitoring blood sugar and reporting any unusual symptoms to your doctor can help manage these potential side effects. For most, these side effects are manageable, but ongoing medical advice is crucial.
How does Invokana compare to other diabetes medications?
This canagliflozin treatment is one of several SGLT2 inhibitors used to manage type 2 diabetes, but it differs from other medications in the same class or from other diabetes treatments like metformin. Here’s a quick comparison:
| Medication | Class | Mechanism of Action | Key Benefits | Common Side Effects |
|---|---|---|---|---|
| Invokana | SGLT2 Inhibitor | Blocks glucose reabsorption in kidneys | Lowers blood sugar, may reduce weight and BP | UTIs, genital infections, dehydration |
| Metformin | Biguanide | Reduces glucose production in the liver | Affordable, improves insulin sensitivity | GI issues like nausea, diarrhea |
| Jardiance | SGLT2 Inhibitor | Similar to canagliflozin; also reduces CV risk | Lower blood sugar, significant CV benefits | UTIs, increased urination, genital issues |
| Glipizide | Sulfonylurea | Stimulates insulin release from the pancreas | Effective at lowering blood sugar quickly | Hypoglycemia, weight gain |
| Ozempic | GLP-1 Receptor Agonist | Increases insulin secretion, slows digestion | Weight loss, lowers blood sugar, CV benefits | Nausea, potential injection site reactions |
Compared to metformin and other older drugs, canagliflozin 100 mg may offer additional benefits for weight management and cardiovascular health, but it comes with a higher cost. While Invokana and Jardiance are similar, some users may prefer one based on specific side effects or their healthcare provider’s recommendation. Always consult with your doctor to choose the most appropriate treatment for your individual needs.
Who should not take Invokana?
Canagliflozin tablets may not be suitable for everyone, especially individuals with specific health conditions. People who should generally avoid Invokana include:
- Those with severe kidney disease or on dialysis: Since the drug works directly in the kidneys, it may not be safe.
- Individuals with frequent urinary tract or genital infections: The drug can increase infection risks in these areas.
- Pregnant or breastfeeding women: The medication’s effects on developing or nursing babies are not fully understood.
- Patients with a history of ketoacidosis: These pills may increase the risk of this condition.
- Anyone with low blood pressure or prone to dehydration: This SGLT2 inhibitor drugcan further lower blood pressure.
Consulting with a doctor before starting type 2 diabetes oral therapy ensures safety and effectiveness.
Is Invokana safe now?
This blood glucose control pill is considered safe for most patients with type 2 diabetes, but it’s essential to use it under the supervision of a healthcare provider. The FDA has approved canagliflozin for blood sugar control and for reducing the risk of heart and kidney complications in high-risk patients. However, this SGLT2 diabetes pill does have some potential risks, such as increased urinary tract infections, genital infections, and a rare risk of ketoacidosis (a serious condition that can occur when the body produces too many ketones). In 2017, the FDA added a boxed warning about an increased risk of lower limb amputation, though the overall risk remains low. Clinical studies have shown that, when taken as directed, Invokana provides significant benefits for heart and kidney health, including a 30% reduction in kidney disease progression. It’s essential to follow your doctor’s advice and undergo regular check-ups to ensure this drug is safe and effective for you.
What drug can replace Invokana?
Several drugs can serve as alternatives to Invokana, especially if a patient experiences side effects or has specific health conditions. Common replacements include Jardiance and Farxiga, which are also SGLT2 inhibitors and have similar mechanisms that reduce blood sugar by promoting glucose excretion through urine. Jardiance, for instance, has been shown to reduce cardiovascular risk by 38% in patients with heart failure, according to the European Society of Cardiology. Other options include GLP-1 receptor agonists like Ozempic or Trulicity, which help manage blood sugar and offer weight loss benefits. Additionally, metformin may be considered, particularly for patients at the start of their treatment journey. Here’s a quick list of potential alternatives:
- Jardiance (empagliflozin): SGLT2 inhibitor with strong cardiovascular benefits
- Farxiga (dapagliflozin): SGLT2 inhibitor, shown to reduce kidney disease progression
- Ozempic (semaglutide): GLP-1 receptor agonist, effective in lowering blood sugar and aiding weight loss
- Metformin: Biguanide, cost-effective first-line therapy for type 2 diabetes
Consulting a healthcare provider can help determine which alternative best fits a patient’s specific health needs.
How long does it stay active in the body?
Invokana is typically active in the body for about 24 hours, which is why it’s taken once daily, usually before breakfast. After ingestion, the tablet starts working within 1 to 2 hours, with its effects lasting throughout the day to help manage blood sugar levels. However, the duration can vary slightly based on individual factors, such as kidney function, age, and overall health. Because canagliflozin works consistently over 24 hours, it allows for steady blood glucose control, helping to prevent large spikes in blood sugar after meals. If you accidentally miss a dose, take it as soon as you remember, unless it’s near your next scheduled dose. Consistency is key with these pills to maintain stable blood sugar levels and optimize treatment outcomes.
Is Invokana the same as Jardiance?
While Invokana and Jardiance both belong to the SGLT2 inhibitor class and are used to manage type 2 diabetes, they have some differences in formulation and specific health benefits. Invokana (canagliflozin) and Jardiance (empagliflozin) work by blocking the SGLT2 protein in the kidneys, preventing glucose from being reabsorbed into the bloodstream and instead allowing it to be excreted through urine. Studies, such as those from the American Diabetes Association (ADA), show that both medications lower blood sugar and contribute to weight loss, with around 2-4% body weight reduction seen in many patients. Jardiance has shown additional cardiovascular benefits, particularly for heart failure patients, making it often preferred for those at high cardiovascular risk. Conversely, canagliflozin tablets have also been studied for kidney health, showing a 30% reduction in progression to end-stage kidney disease. Both are effective, but individual health needs may make one more suitable than the other. A healthcare provider’s guidance can help determine the best choice.
Is Invokana the same as metformin?
Invokana and metformin are both used to treat type 2 diabetes, but they work differently and have distinct benefits and side effects. Here’s a detailed comparison in a table format:
| Feature | Invokana (Canagliflozin) | Metformin |
|---|---|---|
| Class | SGLT2 Inhibitor | Biguanide |
| Mechanism of Action | Blocks glucose reabsorption in the kidneys | Lowers glucose production in the liver |
| Primary Benefit | Blood sugar control, heart and kidney support | Improves insulin sensitivity and blood sugar |
| Additional Benefits | May promote weight loss (2-4% body weight) | Helps with weight management, affordable |
| Cardiovascular Benefits | Shown to reduce cardiovascular events by ~14% | Limited cardiovascular benefits |
| Kidney Health Support | Reduces progression to end-stage kidney disease by ~30% | Not specifically designed for kidney protection |
| Common Side Effects | UTIs, genital infections, dehydration | GI issues (nausea, diarrhea), low risk of hypoglycemia |
| Cost | Generally more expensive | Affordable, often first-line treatment |
| Dosage Frequency | Once daily | Typically twice daily |
| Ideal For | Patients with high cardiovascular or kidney risks | Newly diagnosed patients, first-line therapy |
In many cases, healthcare providers may start patients on metformin due to its affordability and safety profile, adding canagliflozin oral medication later if additional blood sugar or cardiovascular support is needed.
Should I take Invokana in the morning or at night?
The tablet is generally recommended to be taken once daily in the morning, preferably before breakfast. Taking it in the morning helps align with the body’s natural glucose rhythms, supporting consistent blood sugar control throughout the day. Morning dosing also allows patients to monitor for any side effects, like increased urination, during waking hours, which can help avoid dehydration or nighttime disruptions. Consistency is key with canagliflozin treatment, so taking it at the same time each day enhances its effectiveness and helps maintain stable blood glucose levels. If you miss a dose, it’s best to take it as soon as you remember, unless it’s almost time for your next dose. Consult your healthcare provider if you’re considering a different dosing schedule to ensure the medication is optimized for your specific needs.
Does Invokana interact with other medications?
Yes, canagliflozin 100 mg may interact with certain medications, so it’s important to inform your healthcare provider of all prescriptions and supplements you take. Key interactions to be aware of include:
- Diuretics: Can increase the risk of dehydration and low blood pressure.
- Insulin or insulin secretagogues: Combining these with the type 2 diabetes management drug may raise the risk of hypoglycemia (low blood sugar).
- Blood pressure medications: The SGLT2 inhibitor drug may enhance their effect, causing dizziness or lightheadedness.
- Rifampin and phenytoin: These drugs can reduce canagliflozin’s effectiveness.
Regularly reviewing your medication list with your doctor can help avoid potential interactions and keep your treatment plan effective and safe.
Which is better: Jardiance, Invokana, or Farxiga?
Each of these SGLT2 inhibitors has unique strengths, making them suitable for different patient needs. Here’s a comprehensive comparison:
| Feature | Jardiance (Empagliflozin) | Invokana (Canagliflozin) | Farxiga (Dapagliflozin) |
|---|---|---|---|
| Primary Benefit | Excellent for heart failure | Kidney health and cardiovascular support | Balance of heart and kidney benefits |
| Cardiovascular Benefit | Reduces cardiovascular death by 38% | Reduces cardiovascular events by 14% | Reduces heart failure hospitalization by 47% |
| Kidney Health Benefit | Some kidney support | Slows progression to end-stage kidney disease by 30% | Significant reduction in kidney disease progression |
| Average HbA1c Reduction | ~0.8% to 1% | ~0.7% to 1% | ~0.8% to 1% |
| Weight Loss | 2-3% body weight loss | 2-4% body weight loss | 1-3% body weight loss |
| Common Side Effects | UTIs, increased urination | UTIs, dehydration, genital infections | UTIs, mild dehydration |
| FDA Approval for | Type 2 diabetes, heart failure | Type 2 diabetes, kidney disease, heart risk | Type 2 diabetes, heart failure, kidney support |
| Cost | Moderate | Generally more expensive | Similar to Jardiance |
| Best For | Patients with high heart risk | Patients with both kidney and heart risks | Patients needing broad heart and kidney support |
The “better” option depends on individual health goals. Jardiance may be preferable for those primarily at risk for heart failure, while Invokana is often selected for patients with kidney disease concerns. Farxiga is a balanced choice for both heart and kidney support.
What precautions should I take while using these pills?
When taking Invokana, there are several important precautions to consider to ensure safe and effective use:
- Stay well-hydrated: This blood sugar management medication increases urine output, so drinking plenty of fluids is essential to prevent dehydration.
- Maintain a balanced diet with electrolytes: This can help offset any loss due to increased urination.
- Monitor blood pressure: This anti-diabetic medication may lower blood pressure, leading to dizziness, so regular checks are important.
- Conduct frequent kidney function tests: Especially for those with pre-existing kidney concerns.
- Watch for signs of ketoacidosis: Symptoms like nausea, vomiting, and fatigue require immediate medical attention.
- Report infections promptly: Urinary or genital infections are common side effects and should be treated early.
Following these precautions can contribute to safe and effective use of this glucose reabsorption inhibitor.
How much weight can you lose on Invokana?
Weight loss with Invokana varies, but studies have shown that patients may experience a modest reduction in body weight, typically around 2-4% over several months. This weight loss occurs because the drug increases glucose excretion through urine, effectively reducing calorie absorption. For example, in a study published by the American Diabetes Association, patients taking canagliflozin 300 mg experienced an average weight loss of approximately 4.5 pounds (around 2 kg) over 26 weeks. While Invokana is not primarily a weight loss drug, its glucose-lowering effect can help patients achieve some weight reduction as a secondary benefit. For more significant weight loss, healthcare providers may recommend combining canagliflozin tablets with lifestyle modifications like a balanced diet and regular exercise. This combination may optimize both blood sugar control and weight management for better overall health.
Are Invokana and Ozempic the same thing?
No, these are different medications used to manage type 2 diabetes, and they belong to different drug classes with distinct mechanisms of action. Invokana (canagliflozin) is an SGLT2 inhibitor that works by preventing glucose reabsorption in the kidneys, allowing excess sugar to be excreted in urine. This helps lower blood sugar levels and can promote mild weight loss. In contrast, Ozempic (semaglutide) is a GLP-1 receptor agonist, which stimulates insulin release in response to high blood sugar, reduces glucose production in the liver, and slows digestion to help control hunger and blood sugar levels. Both drugs are effective in managing type 2 diabetes, but Ozempic has demonstrated greater weight loss effects, with clinical trials showing an average loss of around 10-15% of body weight. Canagliflozin treatment is often chosen for those needing additional cardiovascular or kidney support, while Ozempic may be preferred for patients looking for more substantial weight loss. Consult your healthcare provider to determine which medication best fits your health goals.
Disclaimer: This information is intended for general knowledge only and should not replace professional medical advice, diagnosis, or treatment. Always consult your healthcare provider before beginning, stopping, or adjusting any medication. Responses to treatments can vary by individual, and only a qualified medical professional can determine the best options for your specific health needs. This information does not cover all possible uses, directions, precautions, or side effects. For any concerns or questions about your treatment, please consult your doctor, pharmacist, or healthcare provider.
Written by Eugen Steiner, M.D., Ph.D.
Medically Reviewed by Ana Stankovic, MD, FACP, FASN, FASH, CHCQM, FABQAURP (Nephrologist)
Last Update on November 6, 2024